Is there a greater impact on society of the opioid epidemic in larger cities?

I have attached the assignment guidelines below PLEASE FOLLOW THEM. the overall topic is the opioid epidemic However my research question is “Is there a greater impact on society of the opioid epidemic in larger cities?” that is what this paper has to touch on and it has to meet all of the points listed in the guidelines.
This is part 4 of a final project so it will have to be added at the end of a large paper.